CHEM 545 - Biochemistry of Cellular Stress Responses

This course will focus on the biochemical pathways and mechanisms activated by cells in response to stress with a special emphasis on proteostatic stress. Topics such as cellular architecture, biochemical signal transduction, types of cellular stress and the sensing mechanisms, and the unfolded protein response (UPR, a homeostatic signaling program that cells mount in response to proteostatic stress) will be covered. Role and regulation of UPR in the context of pathophysiological conditions such as cancer, type II diabetes, neurodegeneration, cardiovascular diseases, and viral infections will be discussed. 

Letter grade only (A-F). Not repeatable for credit.